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  • 1 : Department of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City 702500, Vietnam
  • 2 : Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan
  • 3 : Department of Animal Biotechnology, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City 702500, Vietnam

  • Received 24/03/2018
  • Accepted 29/10/2018
  • Available online 29/11/2018
  • 88
  • 919

Reactive oxygen species (ROS) or oxidative stress has been reported with strongly involving to pathogenesis of many diseases in human. On the other hand, ROS play a critical regulation as secondary signal to maintain intracellular redox equilibrium. Basically, the antioxidant defense systems in the body counteract with overproduced ROS. However, when the redox balance is broken under severe oxidative stress conditions, it leads to tissue injuries and numerous disorders. In this review, we briefly introduce the systems of ROS and antioxidants systems in the body and discuss the opposite roles of ROS in normal physiological conditions and diseases. For ROS-related diseases, conventional and currently developed antioxidant therapies are also described in this review.


reactive oxygen species antioxidant targeting therapy inflammation oxidative stress nanotherapeutics

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