Table 5: Multilevel linear regression assessing the association of NIPS score with SpO₂ and pulse rates per minute adjusting for raters, period (before, during and after clinical intervention) and time (first vs. second assessment) (n=900)

	SpO2 (%)			Pulse rates per minute
	Coef.	p-value	95%CI	Coef.	p-value	95%CI
NIPS score	-0.15	0.40	-0.51; 0.20	3.25	<0.01	1.19; 5.31
Rater 1	1			1
Rater 2	-0.02	0.95	-0.68; 0.63	0.45	0.82	-3.34; 4.24
Rater 3	-0.01	0.98	-0.66; 0.65	0.14	0.94	-3.64; 3.92
Rater 4	-0.00	0.99	-0.66; 0.65	0.05	0.98	-3.72; 3.83
Rater 5	0.01	0.97	-0.64; 0.67	-0.27	0.89	-4.05; 3.51
Before clinical intervention	1			1
During clinical intervention	-15.09	<0.01	-17.50; -12.69	25.54	<0.01	11.62; 39.47
After clinical intervention	-0.14	0.58	-0.65; 0.36	0.05	0.98	-2.90; 2.99
Assessments (second vs. first)	0.01	0.97	-0.41; 0.42	-0.15	0.90	-2.54; 2.24

Multilevel linear regression model; Coef.: Beta coefficient; 95%CI: 95% Confidence Interval.