Table 6. Cytotoxic activity of 2-pyrazoline derivatives
Compound | IC50 (μM) |
HepG2 | RD | MDA-MB-231 |
HP1 | 22.61 | 21.95 | 24.02 |
HP2 | > 100 | 71.19 | > 100 |
HP3 | 55.31 | 32.45 | 40.61 |
HP4 | 63.94 | 28.81 | 26.52 |
HP5 | > 100 | 43.00 | 53.37 |
HP6 | 39.12 | 24.18 | 21.68 |
HP7 | 41.56 | 25.50 | 24.68 |
HP8 | 49.92 | 27.36 | 26.93 |
HP9 | 41.22 | 26.04 | 22.03 |
HP10 | 26.62 | 17.74 | 14.47 |
HP11 | > 100 | 65.60 | 67.88 |
HP12 | 71.09 | 39.08 | 49.31 |
HP13 | > 100 | 69.03 | 60.49 |
HP14 | > 100 | 79.48 | 95.84 |
HP15 | 87.57 | 53.48 | 47.30 |
HP16 | 64.85 | 35.56 | 35.42 |
HP17 | 31.02 | 18.54 | 19.65 |
HP18 | 43.60 | 23.13 | 24.12 |
HP19 | 73.51 | 47.05 | 42.97 |