Table 4. Model of histological fibrosis staging estimation

	Univariate		Multivariate		Reduced multivariate
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
ICG-R15 (double increase)	3.73 (2.11-6.57)	<0.001	1.36 (1.12-1.65)	0.001	2.75 (1.47-5.14)	0.001
Age (+1 year)	-	-	1.03 (1.01-1.04)	0.005	1.02 (1.00-1.04)	0.015
Sex: (Female to Male)	-	-	1.89 (1.00-2.93)	0.019	1.65 (0.97-2.81)	0.066
PLT (+10 G/L)	-	-	0.92 (0.89-0.94)	<0.001	0.92 (0.89-0.94)	<0.001
Serum bilirubin (+10 mmol/L))	-	-	0.89 (0.59-1.34)	0.677	-	-
INR (+0.1)	-	-	1.23 (0.97-1.56)	0.075	-	-
Effectiveness (AUC)	0.59		0.68		0.68

OR: odd ratio for higher Ishak score when variables increase one unit or compare to standard value. CI: confidence interval. ICG-R15: ICG retention rate at 15 minutes. PLT: platelet count. INR: International Normolized Ratio. AUC: area under the curve