Table 3. Relationship between esophageal manifestations of GERD in children with recurrent and chronic respiratory diseases and reflux variants

Indicators	With esophageal symptoms, n = 25	No esophageal symptoms, n = 17	p-value
	Median (IQR)	Median (IQR)
pH-MII parameters by pH channel
DeMeester score	29.54 (7.58-56.015)	5.73 (2.66-15.955)	0.003*
Reflux Index	8.5 (2.05-14.8)	1.1 (0.55-4.45)	0.001*
Acid reflux	84 (34.4-188.1)	26.7 (11-47.1)	0.003*
pH-MII parameters by impedance channel
General reflux1	115.2 (40.7-170.9)	188.8 (122.4-375.9)	0.003*
Acid reflux1	40.5 (11.15-90.05)	26.3 (13.35-56.4)	0.311
Weakly acid reflux1	51.7 (12.35-88.1)	127.6 (53.3-312)	0.001*
Alkaline reflux1	0 (0-4.25)	10.6 (1.75-47.3)	0.001*
Reflux variants according to pH-MII data, frequency
	n (%)	n (%)
Pathological acid reflux2	13 (52)	7 (42)	0.491
Pathological weakly acid reflux2	16 (64)	17 (100)	0.006*
Pathological alkaline reflux2	8 (32)	15 (88)	<0.0001*

Number of episodes in 24 hours,
number of patients with pathological reflux,
p <0.05 was calculated using the nonparametric Mann-Whitney U-test (pH-MII parameters), Chi-square test (frequency of pathological acid and alkaline reflux), Fisher’s exact test (frequency of pathological weakly acid reflux); IQR - interquartile range