Table 1. Characteristics of 151 cancer patients with VTE by age groups, admitted to the department between January 2016 and December 2020

Variable Total (n = 151) Age <70 (n = 83) Age ≥70 (n = 68) P value
Age, median [range] 67 [60-89]
Gender, n (%) 0.937
 Female 55 (36.4) 30 (36.1) 25 (36.8)
 Male 96 (63.6) 53 (63.8) 43 (63.2)
City residence, n (%) 57 (37.6) 29 (34.9) 28 (41.2) 0.432
Body mass index, kg/m2, mean ± SD 21.0 ± 3.3 21.2 ± 3.4 20.8 ± 3.1 0.476
High fall risk (%) 116 (76.8) 66 (79.5) 50 (73.5) 0.386
Comorbidities, n (%)
 Heart failure 3 (2.0) 0 (0.0) 3 (4.4) 0.091§
 Atrial fibrillation 6 (4.0) 2 (2.4) 4 (5.9) 0.412§
 Gastrointestinal bleeding 7 (4.6) 6 (7.2) 1 (1.5) 0.129§
 History of stroke 9 (6.0) 4 (4.8) 5 (7.4) 0.732§
 Ischemic heart disease 14 (9.9) 4 (4.8) 14 (9.9) 0.054§
 Diabetes 28 (18.5) 21 (25.3) 7 (10.3) 0.021§
 Chronic kidney failure 39 (25.8) 10 (12.0) 29 (42.7) <0.001
 Hypertension 52 (34.4) 24 (28.9) 28 (41.2) 0.115
Primary cancer site, n (%)
 Liver (Hepatocarcinoma) 76 (50.0) 43 (51.8) 33 (48.5)
 Lung 22 (14.6) 11 (13.8) 11 (16.2)
 Colon or rectum 9 (6.0) 6 (6.3) 3 (4.4)
 Stomach or esophagus 8 (5.3) 5 (6.3) 3 (4.4)
 Pancreas 6 (4.0) 5 (6.3) 1 (1.5)
 Gallbladder or biliary tract 6 (4.0) 4 (5.0) 2 (2.9)
 Ovary and uterine 4 (2.7) 3 (3.8) 1 (1.5)
 Lymphoma 4 (2.7) 0 (0.0) 4 (5.8)
 Prostate 2 (1.4) 0 (0.0) 2 (2.9)
 Breast 2 (1.4) 1 (1.3) 1 (1.5)
 Kidney 2 (1.4) 0 (0.0) 2 (2.9)
 Others 10 (6.5) 4 (5.4) 6 (7.5)
Clinical stage, n (%) 0.048§
 I 0 0 0
 II 9 (5.9) 4 (4.8) 5 (7.4)
 III 30 (19.9) 11 (13.3) 19 (27.9)
 IV 112 (74.2) 68 (81.9) 44 (64.7)
Cancer at the time of VTE, n (%) 0.993
 Before 0 (0) 0 (0) 0 (0)
 Simultaneous 71 (47.0) 39 (47.0) 32 (47.1)
 After 80 (53.0) 44 (53.0) 36 (52.9)
Metastatic, (%) 112 (74.2) 68 (81.9) 44 (64.7)
Risk factors of VTE
 Any infection, n (%) 60 (39.7) 33 (39.8) 27 (39.7) 0.411
 Immobility, n (%) 117 (77.3) 63 (76.8) 53 (77.9) <0.001
 Recent surgery, n (%) 67 (45.0) 35 (42.7) 32 (47.8) 0.535
 Hospital stay, day, mean ± SD 11.6 ± 8.6 10.7 ± 7.4 12.8 ± 9.9 0.144
Time to VTE diagnosis, median [range] 2 [0; 60] 2 [0; 55] 3.5 [0; 60]
Laboratory findings, mean ± SD
 White blood cells, K/μL 11.4 ± 6.4 11.5 ± 5.8 11.3 ± 7.1 0.820
 Red blood cells, T/L 3.9 ± 0.9 4.1 ± 0.9 3.7 ± 1.0 0.013
 Hemoglobin, g/L 113.7 ± 24.5 116.4 ± 22.6 110.3 ± 26.4 0.127
 Platelet, Giga/L 237.3 ± 125.6 247.7 ± 127.9 224.5 ± 122.6 0.266
 C-reactive protein, mg/L 76.3 ± 68.9 75.9 ± 68.3 76.8 ± 70.4 0.944
 Urea, mg/dL 46.6 ± 47.2 40.7 ± 48.3 53.7 ± 45.0 0.096
 Creatinine, μmol/L 94.3 ± 48.1 84.3 ± 42.5 106.5 ± 51.9 0.004
 ALT, UI/L 63.6 ± 69.1 66.5 ± 65.5 60.1 ± 73.7 0.574
Treatment for cancer, n (%)
 Surgery for cancer 67 (44.4) 35 (42.7) 32 (47.8) 0.535
 Chemotherapy 56 (37.1) 34 (41.5) 22 (32.4) 0.251
 Radiation 16 (10.6) 10 (12.1) 6 (8.8) 0.522
Treatment for VTE, n (%) 0.921§
 Anticoagulation drugs 51 (33.8) 30 (36.1) 21 (30.9)
 IVC filters 2 (1.3) 1 (1.2) 1 (1.5)
 Anticoagulant + IVC filters 2 (1.3) 1 (1.2) 1 (1.5)
 No treatment 96 (63.6) 51 (61.5) 45 (66.2)
The p-value for the difference between age groups was calculated with the independent samples t-test for continuous data and Chi-squared for categorical data
Non-parametric test: Wilcoxon rank-sum test or Fisher’s exact test applied.
Abbreviations: ALT = Alanine aminotransferase; IVC = inferior vena cava; CFS = Clinical Frailty Scale; SD = standard deviation