Table S2. Intention to treat analysis for Comparison of the response after 1-month, 2-month, 3-month, 6-month, 9-month, 12-month, 15-month, 18-month treatment.
| Month | Virological response HBV DNA<250 copies/ml | Biochemical responses HBeAg loss | Serological responses ALT ≤40UI/L |
| Com.(n =105) | Mono. =104) | (n p. | Com. =105) | (n Mono. =104) | (n p. | Com. =105) | (n Mono. =104) | (n p. |
| 0 | 0 (0) | 0 (0) | 1 | 0 (0) | 0 (0) | 1 | 0 (0) | 0 (0) | 1 |
| 1 | # | # | # | # | # | # | 6 (5.7) | 2 (1.9) | 0.280 |
| 2 | # | # | # | # | # | # | 28 (26.7) | 16 (15.4) | 0.061 |
| 3 | 3 (2,9) | 0 (0) | 0.246 | 0 (0) | 0 (0) | 1 | 59 (56.2) | 33 (31.7) | <0.001 |
| 6 | 23 (21.9) | 10 (9.6) | 0.022 | 5 (4.8) | 0 (0) | 0.060 | 81 (77.1) | 52 (50.0) | <0.001 |
| 9 | 54 (51.4) | 31 (29.8) | 0.002 | 12 (11.4) | 1 (1.0) | 0.003 | 88 (83.8) | 67 (64.4) | 0.002 |
| 12 | 79 (75.2) | 62 (59.6) | 0.018 | 19 (18.1) | 8 (7.7) | 0.038 | 95 (90.5) | 76 (73.1) | 0.001 |
| 15 | 94 (89.5) | 77 (74.0) | 0.004 | 28 (26.7) | 14 (13.5) | 0.024 | 99 (94.3) | 86 (82.7) | 0.009 |
| 18 | 97 (92.4) | 88 (84.6) | 0.087 | 35 (33.3) | 21 (20.2) | 0.042 | 99 (94.3) | 91 (87.5) | 0.098 |