Table 2. Comparison of the response after 1-month, 2-month, 3-month, 6-month, 9-month, 12-month, 15-month, 18-month treatment

Month	Virological response HBV DNA<250 copies/ml			Biochemical responses HBeAg loss			Serological responses ALT ≤40UI/L
	Com.(n =100)	Mono. (n =100)	p.	Com. (n =100)	Mono. (n =100)	p.	Com. (n =100)	Mono. (n =100)	p.
0	0 (0%)	0	1	0	0	1	0	0	1
1	#	#	#	#	#	#	6 (6%)	2 (2%)	0.279
2	#	#	#	#	#	#	28 (28%)	16 (16%)	0.060
3	3 (3%)	0	0.246	0	0	#	59 (59%)	33 (33%)	<0.001
6	23 (23%)	10 (10%)	0.021	5 (5%)	0	0.059	81 (81%)	52 (52%)	<0.001
9	54 (54%)	31 (31%)	0.002	12 (12%)	1 (1%)	0.003	88 (88%)	67 (67%)	0.001
12	79 (79%)	62 (62%)	0.013	19 (19%)	8 (8%)	0.037	95 (95%)	76 (76%)	<0.001
15	94 (94%)	77 (77%)	0.001	28 (28%)	14 (14%)	0.023	99 (99%)	86 (86%)	0.001
18	97 (97%)	88 (88%)	0.029	35 (35%)	21 (21%)	0.040	99 (99%)	91 (91%)	0.018

p. Fisher’s exact test; Com. combination therapy group; Mono. monotherapy group