Table 6. The biological response (the proportion of ALT normalization) response in hepatitis B patients treated by TDF

	3^rd month	6^th month	12^th month	18^th month
Dachuan Cai (2019) [14]	44.59%	66.88%	81.94%	84.97%
Rong-Yue Liang (2019) [15]	52.73%	71.95%	82.93%
Patrick Marcellin (2015) [17]	-	-	63.1%	72.7%
Our study (mono. group)	33%	52%	76%	91%
Our study (com. group)	59%	81%	95%	99%