Table S1. Test for normality distribution of quantitative variable

	p-value of normality test by methods				Normality distribution (True/False)
	Skewness test	Kurtosis test	Chi-square test for Skewness & Kurtosis combined	Doornik-Hansen test for overall
Age (year)	0.043	0.620	0.110	0.049	False
Liver enzymes (UI/L) at T0
ALT	<0.001	0.004	<0.001	<0.001	False
AST	<0.001	0.002	<0.001	<0.001	False
GGT	<0.001	<0.001	<0.001	<0.001	False
Creatinin by month
T0	0.427	0.097	0.181	0.246	True
T1	0.225	0.570	0.404	0.285	True
T2	<0.001	<0.001	<0.001	<0.001	False
T3	0.012	0.852	0.046	0.007	False
T6	0.284	0.642	0.502	0.456	True
T9	<0.001	<0.001	<0.001	<0.001	False
T12	0.007	0.058	0.008	0.020	False
T15	0.383	0.148	0.236	0.294	True
T18	<0.001	<0.001	<0.001	<0.001	False
Multivariate test for overall	<0.001	<0.001		<0.001	False