Table 1. Range and level of parameters in the design

Variables Levels
−2 −1 0 +1 +2
Temperature (°C) (X1) 45 60 75 90 105
Ratio 1 (X2) 0.5 2 3.5 5 6.5
Ratio 2 (X3) 1.5 3 4.5 6 7.5
Time (hour) (X4) 1 3 5 7 9