MedPharmRes

About MedPharmRes

The University of Medicine and Pharmacy at Ho Chi Minh City is pleased to announce its first English journal MedPharmRes (Publication permit 121a/GP-BTTTT of March 23, 2017 by the Ministry of Information and Communications of the Socialist Republic of Vietnam). MedPharmRes is proud to be an English open access peer reviewed journal that delivers cutting edge research in various aspects of medicine, pharmacy, dentistry and other health sciences. Currently, the new permit is numbered 52/GP-BTTTT, issued on March 6, 2024.
Review Article

Mar 31, 2025

Updated biomarkers for extracellular traps from neutrophil, monocyte, and M1 macrophage in neutrophilic asthma: a narrative review

Quoc Quang Luu, Thi Bich Tra Cao, Hae-Sim Park, Duy Le Pham

MedPharmRes 2025;9(1):1-16.
https://doi.org/10.32895/UMP.MPR.9.1.1

Asthma, a common chronic inflammatory condition in the airways, significantly impacts individuals across all age groups and poses a substantial global health burden. Despite the availability of conventional treatments, a considerable proportion of asthmatic patients continue to experience uncontrolled asthma symptoms. This review focuses on neutrophilic asthma (NA), a challenging endotype characterized by lower lung function, a higher frequency of symptom exacerbations, and a poorer response to standard therapies. NA is typically diagnosed by a...
Original Article

Mar 31, 2025

Prevalence of overexpressed resistance nodulation division (RND) efflux pumps of Pseudomonas aeruginosa causing nosocomial infections in several hospitals in Ho Chi Minh City

Ngan Thuy Duong, Tuan Minh Huynh, Anh Tuan Le

MedPharmRes 2025;9(1):17-28.
https://doi.org/10.32895/UMP.MPR.9.1.2

Introduction: Pseudomonas aeruginosa is a prevalent nosocomial pathogen known for its extensive antibiotic resistance. The overexpression of antibiotic efflux systems plays crucial role in the resistance patterns of this bacterium. Nevertheless, studies on the prevalence of efflux pump overexpression in P. aeruginosa in Vietnam remain limited. Methods: From May to July 2023, all strains suspected to be P. aeruginosa were collected from inpatents at the University Medical Center of Ho Chi Minh City, and Le Van Thinh Hospital, Ho Chi Minh City, V...
Original Article

Mar 31, 2025

Surgical treatment for biliary obstruction in patients with painful chronic pancreatitis and a dilated duct: choledochojejunostomy or biliopancreatic tunneling?

Dai Nga Mai, Quoc Vinh Nguyen, Minh Tri Phan, Tien My Doan

MedPharmRes 2025;9(1):29-38.
https://doi.org/10.32895/UMP.MPR.9.1.3

Introduction: Patients with painful chronic pancreatitis and a dilated duct are treated with extended surgical drainage procedures such as Frey or extended Partington procedures. In cases of biliary obstruction, an additional biliary derivation is performed. Either concurrent choledochojejunostomy or biliopancreatic tunneling may be chosen in such cases. Methods: To assess the results of surgical treatment for biliary obstruction in patients with painful chronic pancreatitis and a dilated main pancreatic duct. This study was a case series compr...
Original Article

Mar 31, 2025

Eye lens dose survey for medical staff in interventional cardiology: preliminary results

Tuyen Nhu Pham, Nham Thi Thuy Nguyen, Nhi Yen Tran, Hoang Anh Ta, Luong Thanh Dang

MedPharmRes 2025;9(1):39-48.
https://doi.org/10.32895/UMP.MPR.9.1.4

Introduction: In 2011, the International Commission on Radiological Protection (ICRP) recommended reducing the occupational dose limit for eye lens, Heye lens, from 150 mSv/year to 20 mSv/year. Many countries, including Vietnam, have incorporated the new recommended dose limits into their radiation safety regulations. This study aims to evaluate radiation dose to the eyes of cardiovascular interventional radiology staff in one hospital to assess whether the new dose limits are likely to be exceeded in the unit. At the same time, determine the s...
Original Article

Mar 31, 2025

Optimization of the synthesis reaction and establishing the reference standard of Fenofibrate impurity C (USP)

Tran Van-Hoai Le, Tuyen Ngoc Truong, Thuong Thi-Thuong Le, Dung Thanh Phan

MedPharmRes 2025;9(1):49-61.
https://doi.org/10.32895/UMP.MPR.9.1.5

Introduction: 1-methylethyl 2-[[2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl propanoyl]oxy]-2-methylpropanoate (or fenofibrate impurity C, United States Pharmacopoeia [USP]) is an impurity in fenofibrate raw material. To date, publications on synthesis of fenofibrate impurity C (ImpC) have reported low yield and purity, so far. The purpose of this study is to optimize the conditions for synthesis of ImpC using Central Composite Design (CCD) approach and standardization of ImpC as reference substance. Methods: ImpC was synthesized from the reaction b...
Original Article

Mar 31, 2025

Effects of internet addiction and smartphone addiction on the sleep quality of students of the Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City in 2023

Minh Quang Lam, Nhat Duyet Pham, Linh Thy Le, Thi Thu Ha Dam

MedPharmRes 2025;9(1):62-73.
https://doi.org/10.32895/UMP.MPR.9.1.6

Introduction: Internet addiction and smartphone addiction are global dilemmas. Excessive misuse of smartphones or the internet can adversely affect users’ health, psychological, spiritual, and quality of life. On the other hand, sleep has been considered one of the factors that make people’s lives and spirits the most comfortable. However, smartphone and internet addiction can adversely affect users’ sleep, especially in adolescents who are easily tempted and love to learn. Therefore, this study was conducted to determine the influence of...
Original Article

Mar 31, 2025

Validity and reliability of the Vietnamese version of the readiness for interprofessional learning scale

Khoa Duy Duong, Duong Dai Le, Tuong Thi Kim Nguyen, Chung Huynh, Hoang Thi Mai Nguyen, Linh Thuy Khanh Tran, Bao Khac Le

MedPharmRes 2025;9(1):74-83.
https://doi.org/10.32895/UMP.MPR.9.1.7

Introduction: The World Health Organization recommends interprofessional education (IPE) to cultivate a collaborative workforce and enhance health outcomes. Despite the growing prominence of IPE in Vietnam, a validated instrument to assess student attitudes is lacking. While the 19-item version of Readiness for Interprofessional Learning Scale (RIPLS) has been translated into Vietnamese, its psychometric properties remain unexplored. This study aimed to assess the validity and reliability of the Vietnamese RIPLS, providing educators with a cred...
Original Article

Mar 31, 2025

The Clinical Frailty Scale version 2.0: Translation and defining reliability in Vietnamese older patients

Tri Van Nguyen, Tran To Tran Nguyen, Tuan Chau Nguyen, Tai Huy Kien Pham

MedPharmRes 2025;9(1):84-94.
https://doi.org/10.32895/UMP.MPR.9.1.8

Introduction: The Clinical Frailty Scale (CFS) is a practical, reliable, and judgment-based tool among many instruments used for detecting frailty in older adults. However, the CFS has not yet been culturally adapted or validated in the Vietnamese language. This study aimed to translate the CFS into Vietnamese and evaluate the reliability of the Vietnamese CFS version in older adults. Methods: The prospective study recruited outpatients aged 60 years and older at a geriatric outpatient clinic of a public hospital in Vietnam between September 20...
Original Article

Mar 31, 2025

Antifungal and antitumor activities of cellulose-degrading myxobacteria isolated from soil in Vietnam

Minh Trong Quang, Khue Nhu Thi Duong, Tam Bao Ngoc Tran, Dieu Xuan Mai Do, Thien Mai Nguyen, Duy Anh Hoang Nguyen, Thai Minh Nguyen

MedPharmRes 2025;9(1):95-105.
https://doi.org/10.32895/UMP.MPR.9.1.9

Introduction: Myxobacteria are known to produce epothilone, a natural macrolide compound with significant antitumor activity achieved through the inhibition of microtubules formation during cell division, which is a mechanism critical to chemotherapy. This study investigated the antifungal and antitumor activities of myxobacteria isolated from soils enriched with decomposed plant material. Methods: Myxobacterial strains were isolated and screened by examining macroscopic characteristics, assessing cellulose degradation using filter paper as the...
Original Article

Mar 31, 2025

In vitro activities of leaf and root extracts of Catharanthus roseus (L.) G. Don. on human peripheral blood mononuclear cells

Thuan Thi Minh Nguyen, Vi Thi Ha Luong, Anh Thi Bao Nguyen

MedPharmRes 2025;9(1):106-120.
https://doi.org/10.32895/UMP.MPR.9.1.10

Introduction: Catharanthus roseus (L.) G.Don. is widely used to treat hypertension, diabetes, poor digestion and dysentery, and fever. However, studies on the pharmacological effects on the immunomodulatory of C. roseus have been limited. The objective of this study was to investigate the immunomodulatory activity of leaf and root extracts of C. roseus on human peripheral blood mononuclear cells (PBMCs). Methods: PBMCs were isolated from 10 mL of EDTA–coagulated whole blood collected from the healthy volunteers. The effects of 96% ethanol ext...
Original Article

Mar 31, 2025

Influence of formulation and punch properties on sticking in the tableting process

Minh-Quan Le, Khuong-Nhi Cao-Nguyen, Kieu-Trinh Nguyen-Tran, Van-Ha Nguyen, Hau Le

MedPharmRes 2025;9(1):121-133.
https://doi.org/10.32895/UMP.MPR.9.1.11

Introduction: Punch sticking is a common phenomenon in tablet manufacturing, often leading to tablet defects and compromise product quality. A thorough understanding of the sticking mechanism is essential to optimize the tablet production process. The aim of this study was to investigate the influence of formulations and punch properties on sticking. Methods: Seven model active pharmaceutical ingredients (APIs) (i.e., ibuprofen, aspirin, paracetamol, metronidazole, diltiazem, diclofenac, and cefuroxime) with various melting points and particle ...
Case Report

Mar 31, 2025

Reversal of third-degree atrioventricular block in a long-term dialysis patient by temporary transvenous pacing: a case report

Minh Duc Dang, Anh My Bui, Dung Tien Nguyen, Chih-Chin Kao, Tu Tuan Tran

MedPharmRes 2025;9(1):134-140.
https://doi.org/10.32895/UMP.MPR.9.1.12

In hemodialysis patients, arrhythmias are a significant concern due to mineral bone disease, despite efforts to address abnormalities in plasma calcium and phosphorus levels. Metastatic calcification, the abnormal accumulation of calcium in soft tissues, is a common consequence of these metabolic disorders and can contribute to the development of cardiac conduction issues. This case report is significant as it emphasizes the serious cardiovascular risks associated with metastatic calcification in hemodialysis patients, particularly its role in ...

CURRENT ISSUE: Mar 2025, Vol. 9, No. 1

Review Article Updated biomarkers for extracellular traps from neutrophil, monocyte, and M1 macrophage in neutrophilic asthma: a narrative review Quoc Quang Luu, Thi Bich Tra Cao, Hae-Sim Park, Duy Le Pham MedPharmRes 2025;9(1):1-16. https://doi.org/10.32895/UMP.MPR.9.1.1 HTML PDF PubReader	Original Article Prevalence of overexpressed resistance nodulation division (RND) efflux pumps of Pseudomonas aeruginosa causing nosocomial infections in several hospitals in Ho Chi Minh City Ngan Thuy Duong, Tuan Minh Huynh, Anh Tuan Le MedPharmRes 2025;9(1):17-28. https://doi.org/10.32895/UMP.MPR.9.1.2 HTML PDF PubReader
Original Article Surgical treatment for biliary obstruction in patients with painful chronic pancreatitis and a dilated duct: choledochojejunostomy or biliopancreatic tunneling? Dai Nga Mai, Quoc Vinh Nguyen, Minh Tri Phan, Tien My Doan MedPharmRes 2025;9(1):29-38. https://doi.org/10.32895/UMP.MPR.9.1.3 HTML PDF PubReader	Original Article Eye lens dose survey for medical staff in interventional cardiology: preliminary results Tuyen Nhu Pham, Nham Thi Thuy Nguyen, Nhi Yen Tran, Hoang Anh Ta, Luong Thanh Dang MedPharmRes 2025;9(1):39-48. https://doi.org/10.32895/UMP.MPR.9.1.4 HTML PDF PubReader
Original Article Optimization of the synthesis reaction and establishing the reference standard of Fenofibrate impurity C (USP) Tran Van-Hoai Le, Tuyen Ngoc Truong, Thuong Thi-Thuong Le, Dung Thanh Phan MedPharmRes 2025;9(1):49-61. https://doi.org/10.32895/UMP.MPR.9.1.5 HTML PDF PubReader	Original Article Effects of internet addiction and smartphone addiction on the sleep quality of students of the Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City in 2023 Minh Quang Lam, Nhat Duyet Pham, Linh Thy Le, Thi Thu Ha Dam MedPharmRes 2025;9(1):62-73. https://doi.org/10.32895/UMP.MPR.9.1.6 HTML PDF PubReader
Original Article Validity and reliability of the Vietnamese version of the readiness for interprofessional learning scale Khoa Duy Duong, Duong Dai Le, Tuong Thi Kim Nguyen, Chung Huynh, Hoang Thi Mai Nguyen, Linh Thuy Khanh Tran, Bao Khac Le MedPharmRes 2025;9(1):74-83. https://doi.org/10.32895/UMP.MPR.9.1.7 HTML PDF PubReader	Original Article The Clinical Frailty Scale version 2.0: Translation and defining reliability in Vietnamese older patients Tri Van Nguyen, Tran To Tran Nguyen, Tuan Chau Nguyen, Tai Huy Kien Pham MedPharmRes 2025;9(1):84-94. https://doi.org/10.32895/UMP.MPR.9.1.8 HTML PDF PubReader
Original Article Antifungal and antitumor activities of cellulose-degrading myxobacteria isolated from soil in Vietnam Minh Trong Quang, Khue Nhu Thi Duong, Tam Bao Ngoc Tran, Dieu Xuan Mai Do, Thien Mai Nguyen, Duy Anh Hoang Nguyen, Thai Minh Nguyen MedPharmRes 2025;9(1):95-105. https://doi.org/10.32895/UMP.MPR.9.1.9 HTML PDF PubReader	Original Article In vitro activities of leaf and root extracts of Catharanthus roseus (L.) G. Don. on human peripheral blood mononuclear cells Thuan Thi Minh Nguyen, Vi Thi Ha Luong, Anh Thi Bao Nguyen MedPharmRes 2025;9(1):106-120. https://doi.org/10.32895/UMP.MPR.9.1.10 HTML PDF PubReader
Original Article Influence of formulation and punch properties on sticking in the tableting process Minh-Quan Le, Khuong-Nhi Cao-Nguyen, Kieu-Trinh Nguyen-Tran, Van-Ha Nguyen, Hau Le MedPharmRes 2025;9(1):121-133. https://doi.org/10.32895/UMP.MPR.9.1.11 HTML PDF PubReader	Case Report Reversal of third-degree atrioventricular block in a long-term dialysis patient by temporary transvenous pacing: a case report Minh Duc Dang, Anh My Bui, Dung Tien Nguyen, Chih-Chin Kao, Tu Tuan Tran MedPharmRes 2025;9(1):134-140. https://doi.org/10.32895/UMP.MPR.9.1.12 HTML PDF PubReader

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